NF_kB_complex -> IFNB1_space_expression_space_complex_complex
IRF3_phosphorylated -> IFNB1_space_expression_space_complex_complex
cGAMP_STING_complex_Endoplamatic_space_reticulum -> cGAMP_STING_complex_Perinuclear_space_Golgi
cGAMP_simple_molecule -> cGAMP_STING_complex_Endoplamatic_space_reticulum
STING_Endoplamatic_space_reticulum -> cGAMP_STING_complex_Endoplamatic_space_reticulum
WIPI2 -> cGAMP_STING_LC3_complex
cGAMP_STING_complex -> cGAMP_STING_LC3_complex
dsDNA_simple_molecule -> cGAS_dsDNA_complex
cGAS -> cGAS_dsDNA_complex
TBK1 -> STING_TBK1_complex_Perinuclear_space_Golgi
cGAMP_STING_complex_Perinuclear_space_Golgi -> STING_TBK1_complex_Perinuclear_space_Golgi
STING_Perinuclear_space_Golgi -> STING_TBK1_complex_Perinuclear_space_Golgi
cGAMP_STING_complex_Endoplamatic_space_reticulum -> cGAMP_STING_complex
SAR1A -> cGAMP_STING_complex
STING_TBK1_complex_Perinuclear_space_Golgi -> STING_TBK1_complex_Endolysozome
MRE11_RAD50_DNA_complex_Pulmonary_space_endothelial_space_cell -> MRE11_RAD50_DNA_complex_Endoplamatic_space_reticulum
dsDNA_simple_molecule -> MRE11_RAD50_DNA_complex_Pulmonary_space_endothelial_space_cell
MRE11 -> MRE11_RAD50_DNA_complex_Pulmonary_space_endothelial_space_cell
uridine_simple_molecule -> UMP_simple_molecule
UCK2 -> UMP_simple_molecule
orotidine_space_5__monophosphate_simple_molecule -> UMP_simple_molecule
UMPS -> UMP_simple_molecule
sa81_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell -> cGAMP_simple_molecule
GTP_simple_molecule -> cGAMP_simple_molecule
cGAS_dsDNA_complex -> cGAMP_simple_molecule
RTC_and_transcription_pw_phenotype -> RNA_space_biosynthesis_phenotype
N_carbamoyl_L_aspartate_simple_molecule -> sa18_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell
H_simple_molecule -> sa18_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell
CAD -> sa18_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell
CDP_simple_molecule -> dCDP_simple_molecule
ribonucleoside_diphosphate_reductase_complex -> dCDP_simple_molecule
UMP_simple_molecule -> UDP_simple_molecule
CMPK -> UDP_simple_molecule
dUMP_simple_molecule -> dTMP_simple_molecule
TYMS -> dTMP_simple_molecule
IFNA1_rna -> IFNA1_Pulmonary_space_endothelial_space_cell
L_Gln_simple_molecule -> sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
HCO3_simple_molecule -> sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell -> sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell -> sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
CAD -> sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
N_carbamoyl_L_aspartate_simple_molecule -> _S__dihydroorotate_simple_molecule
H_simple_molecule -> _S__dihydroorotate_simple_molecule
CAD -> _S__dihydroorotate_simple_molecule
L_Gln_simple_molecule -> ADP_simple_molecule
HCO3_simple_molecule -> ADP_simple_molecule
sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell -> ADP_simple_molecule
sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell -> ADP_simple_molecule
CAD -> ADP_simple_molecule
dUTP_simple_molecule -> dUMP_simple_molecule
DUT -> dUMP_simple_molecule
dCMP_simple_molecule -> dUMP_simple_molecule
DCTD -> dUMP_simple_molecule
CAP_simple_molecule -> N_carbamoyl_L_aspartate_simple_molecule
L_Asp_simple_molecule -> N_carbamoyl_L_aspartate_simple_molecule
CAD -> N_carbamoyl_L_aspartate_simple_molecule
cytidine_simple_molecule -> CMP_simple_molecule
UCK2 -> CMP_simple_molecule
CMP_simple_molecule -> CDP_simple_molecule
CMPK -> CDP_simple_molecule
IFNB1_Pulmonary_space_endothelial_space_cell -> IFNB1_default_compartment
dsDNA_simple_molecule -> DNA_gene
dTTP_simple_molecule -> DNA_gene
DNA_space_biosynthesis_phenotype -> DNA_gene
virus_space_replication_phenotype -| DNA_gene
dTMP_simple_molecule -> dTDP_simple_molecule
dTYMK -> dTDP_simple_molecule
DNA_damage_phenotype -> dsDNA_simple_molecule
IFNB1_space_expression_space_complex_complex -> IFNA1_rna
UDP_simple_molecule -> UTP_simple_molecule
sa42_NME1_Pulmonary_space_endothelial_space_cell -> UTP_simple_molecule
dTDP_simple_molecule -> dTTP_simple_molecule
orotate_simple_molecule -> PPi_simple_molecule
PRPP_simple_molecule -> PPi_simple_molecule
UMPS -> PPi_simple_molecule
L_Gln_simple_molecule -> L_Glu_simple_molecule
HCO3_simple_molecule -> L_Glu_simple_molecule
sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell -> L_Glu_simple_molecule
sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell -> L_Glu_simple_molecule
CAD -> L_Glu_simple_molecule
cytidine_simple_molecule -> uridine_simple_molecule
CDA -> uridine_simple_molecule
IFNB1_rna -> IFNB1_Pulmonary_space_endothelial_space_cell
IFNA1_Pulmonary_space_endothelial_space_cell -> IFNA1_default_compartment
L_Gln_simple_molecule -> CAP_simple_molecule
HCO3_simple_molecule -> CAP_simple_molecule
sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell -> CAP_simple_molecule
sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell -> CAP_simple_molecule
CAD -> CAP_simple_molecule
dCTP_simple_molecule -> dCMP_simple_molecule
DCTPP1 -> dCMP_simple_molecule
STING_Endoplamatic_space_reticulum -> STING_Perinuclear_space_Golgi
MRE11_RAD50_DNA_complex_Endoplamatic_space_reticulum -> STING_Perinuclear_space_Golgi
dCDP_simple_molecule -> dCTP_simple_molecule
sa51_NME1_Pulmonary_space_endothelial_space_cell -> dCTP_simple_molecule
STING_TBK1_complex_Endolysozome -> IRF3_phosphorylated
_S__dihydroorotate_simple_molecule -> QH2_simple_molecule
CoQ_simple_molecule -> QH2_simple_molecule
dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule -> QH2_simple_molecule
P1788_simple_molecule -| QH2_simple_molecule
Teriflunomide_drug -| QH2_simple_molecule
orotate_simple_molecule -> orotidine_space_5__monophosphate_simple_molecule
PRPP_simple_molecule -> orotidine_space_5__monophosphate_simple_molecule
UMPS -> orotidine_space_5__monophosphate_simple_molecule
dUDP_simple_molecule -> dUTP_simple_molecule
sa51_NME1_Pulmonary_space_endothelial_space_cell -> dUTP_simple_molecule
_S__dihydroorotate_simple_molecule -> orotate_simple_molecule
CoQ_simple_molecule -> orotate_simple_molecule
dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule -> orotate_simple_molecule
P1788_simple_molecule -| orotate_simple_molecule
Teriflunomide_drug -| orotate_simple_molecule
orotidine_space_5__monophosphate_simple_molecule -> CO2_simple_molecule
UMPS -> CO2_simple_molecule
UTP_simple_molecule -> CTP_simple_molecule
CTPS1 -> CTP_simple_molecule
CDP_simple_molecule -> CTP_simple_molecule
sa42_NME1_Pulmonary_space_endothelial_space_cell -> CTP_simple_molecule
UDP_simple_molecule -> dUDP_simple_molecule
ribonucleoside_diphosphate_reductase_complex -> dUDP_simple_molecule
CAP_simple_molecule -> sa15_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
L_Asp_simple_molecule -> sa15_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
CAD -> sa15_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell
IFNB1_space_expression_space_complex_complex -> IFNB1_rna
CTP_simple_molecule -> RTC_and_transcription_pw_phenotype
Teriflunomide_drug -> DNA_damage_phenotype
IFNB1_default_compartment -> HCoVs_Type_I_Ifn_signalling_WP4868__phenotype
IFNA1_default_compartment -> HCoVs_Type_I_Ifn_signalling_WP4868__phenotype
IFNB1_default_compartment -> Interferon_1_pathway_phenotype
IFNA1_default_compartment -> Interferon_1_pathway_phenotype
cGAMP_STING_LC3_complex -> HCoVs_autophagy__WP4863__phenotype
IFNA1_default_compartment -> HCoVs_IFN_induction_WP4880_phenotype
IFNB1_default_compartment -> HCoVs_IFN_induction_WP4880_phenotype
$ADP_simple_molecule: ((((L_Gln_simple_molecule & HCO3_simple_molecule) & sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell) & sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell) & CAD)
$CAP_simple_molecule: ((((L_Gln_simple_molecule & HCO3_simple_molecule) & sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell) & sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell) & CAD)
$CDP_simple_molecule: (CMP_simple_molecule & CMPK)
$CMP_simple_molecule: (cytidine_simple_molecule & UCK2)
$CO2_simple_molecule: (orotidine_space_5__monophosphate_simple_molecule & UMPS)
$CTP_simple_molecule: ((UTP_simple_molecule & CTPS1) | (CDP_simple_molecule & sa42_NME1_Pulmonary_space_endothelial_space_cell))
$DNA_damage_phenotype: Teriflunomide_drug
$DNA_gene: (((dsDNA_simple_molecule & dTTP_simple_molecule) & DNA_space_biosynthesis_phenotype) & !virus_space_replication_phenotype)
$HCoVs_IFN_induction_WP4880_phenotype: (IFNA1_default_compartment | IFNB1_default_compartment)
$HCoVs_Type_I_Ifn_signalling_WP4868__phenotype: (IFNB1_default_compartment | IFNA1_default_compartment)
$HCoVs_autophagy__WP4863__phenotype: cGAMP_STING_LC3_complex
$IFNA1_Pulmonary_space_endothelial_space_cell: IFNA1_rna
$IFNA1_default_compartment: IFNA1_Pulmonary_space_endothelial_space_cell
$IFNA1_rna: IFNB1_space_expression_space_complex_complex
$IFNB1_Pulmonary_space_endothelial_space_cell: IFNB1_rna
$IFNB1_default_compartment: IFNB1_Pulmonary_space_endothelial_space_cell
$IFNB1_rna: IFNB1_space_expression_space_complex_complex
$IFNB1_space_expression_space_complex_complex: (NF_kB_complex & IRF3_phosphorylated)
$IRF3_phosphorylated: STING_TBK1_complex_Endolysozome
$Interferon_1_pathway_phenotype: (IFNB1_default_compartment | IFNA1_default_compartment)
$L_Glu_simple_molecule: ((((L_Gln_simple_molecule & HCO3_simple_molecule) & sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell) & sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell) & CAD)
$MRE11_RAD50_DNA_complex_Endoplamatic_space_reticulum: MRE11_RAD50_DNA_complex_Pulmonary_space_endothelial_space_cell
$MRE11_RAD50_DNA_complex_Pulmonary_space_endothelial_space_cell: (dsDNA_simple_molecule & MRE11)
$N_carbamoyl_L_aspartate_simple_molecule: ((CAP_simple_molecule & L_Asp_simple_molecule) & CAD)
$PPi_simple_molecule: ((orotate_simple_molecule & PRPP_simple_molecule) & UMPS)
$QH2_simple_molecule: ((((_S__dihydroorotate_simple_molecule & CoQ_simple_molecule) & dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule) & !P1788_simple_molecule) & !Teriflunomide_drug)
$RNA_space_biosynthesis_phenotype: RTC_and_transcription_pw_phenotype
$RTC_and_transcription_pw_phenotype: CTP_simple_molecule
$STING_Perinuclear_space_Golgi: (STING_Endoplamatic_space_reticulum & MRE11_RAD50_DNA_complex_Endoplamatic_space_reticulum)
$STING_TBK1_complex_Endolysozome: STING_TBK1_complex_Perinuclear_space_Golgi
$STING_TBK1_complex_Perinuclear_space_Golgi: ((TBK1 & cGAMP_STING_complex_Perinuclear_space_Golgi) | (TBK1 & STING_Perinuclear_space_Golgi))
$UDP_simple_molecule: (UMP_simple_molecule & CMPK)
$UMP_simple_molecule: ((uridine_simple_molecule & UCK2) | (orotidine_space_5__monophosphate_simple_molecule & UMPS))
$UTP_simple_molecule: (UDP_simple_molecule & sa42_NME1_Pulmonary_space_endothelial_space_cell)
$_S__dihydroorotate_simple_molecule: ((N_carbamoyl_L_aspartate_simple_molecule & H_simple_molecule) & CAD)
$cGAMP_STING_LC3_complex: (WIPI2 | cGAMP_STING_complex)
$cGAMP_STING_complex: (cGAMP_STING_complex_Endoplamatic_space_reticulum & SAR1A)
$cGAMP_STING_complex_Endoplamatic_space_reticulum: (cGAMP_simple_molecule & STING_Endoplamatic_space_reticulum)
$cGAMP_STING_complex_Perinuclear_space_Golgi: cGAMP_STING_complex_Endoplamatic_space_reticulum
$cGAMP_simple_molecule: ((sa81_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell & GTP_simple_molecule) & cGAS_dsDNA_complex)
$cGAS_dsDNA_complex: (dsDNA_simple_molecule & cGAS)
$dCDP_simple_molecule: (CDP_simple_molecule & ribonucleoside_diphosphate_reductase_complex)
$dCMP_simple_molecule: (dCTP_simple_molecule & DCTPP1)
$dCTP_simple_molecule: (dCDP_simple_molecule & sa51_NME1_Pulmonary_space_endothelial_space_cell)
$dTDP_simple_molecule: (dTMP_simple_molecule & dTYMK)
$dTMP_simple_molecule: (dUMP_simple_molecule & TYMS)
$dTTP_simple_molecule: dTDP_simple_molecule
$dUDP_simple_molecule: (UDP_simple_molecule & ribonucleoside_diphosphate_reductase_complex)
$dUMP_simple_molecule: ((dUTP_simple_molecule & DUT) | (dCMP_simple_molecule & DCTD))
$dUTP_simple_molecule: (dUDP_simple_molecule & sa51_NME1_Pulmonary_space_endothelial_space_cell)
$dsDNA_simple_molecule: DNA_damage_phenotype
$orotate_simple_molecule: ((((_S__dihydroorotate_simple_molecule & CoQ_simple_molecule) & dihydroorotate_space_dehydrogenase_space_holoenzyme_simple_molecule) & !P1788_simple_molecule) & !Teriflunomide_drug)
$orotidine_space_5__monophosphate_simple_molecule: ((orotate_simple_molecule & PRPP_simple_molecule) & UMPS)
$sa14_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell: ((((L_Gln_simple_molecule & HCO3_simple_molecule) & sa8_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell) & sa9_ATP_simple_molecule_Pulmonary_space_endothelial_space_cell) & CAD)
$sa15_Pi_simple_molecule_Pulmonary_space_endothelial_space_cell: ((CAP_simple_molecule & L_Asp_simple_molecule) & CAD)
$sa18_H2O_simple_molecule_Pulmonary_space_endothelial_space_cell: ((N_carbamoyl_L_aspartate_simple_molecule & H_simple_molecule) & CAD)
$uridine_simple_molecule: (cytidine_simple_molecule & CDA)